Size-Dependent Kinetics Associated with Drug Block of Sodium Current
نویسندگان
چکیده
منابع مشابه
Size-dependent Kinetics Determination of MoS2-K2O/CNTS Nanocatalyst in the Synthesis of Alcohols from Syngas
The influence of Mo particle size on the catalytic activity and product selectivity of alkalized MoS2 nanocatalysts has been investigated. Nanocatalysts are prepared using a microemulsion technique with water-to-surfactant ratios of 1-12. Three different techniques, including XRD, TEM, and hydrogen chemisorption were used to determine the molybdenum average particle size and their activity and ...
متن کاملPsoriasiform Drug Eruption Associated with Sodium Valproate
As psoriasis is a common skin disorder, knowledge of the factors that may induce, trigger, or exacerbate the disease is of primary importance in clinical practice. Drug intake is a major concern in this respect, as new drugs are constantly being added to the list of factors that may influence the course of the disease. We report a patient with a psoriasiform drug eruption associated with the us...
متن کاملMechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics.
beta-Adrenergic modulation is one of the most important regulatory mechanisms of ion channel function. Only recently, however, have beta-adrenergic effects on cardiac Na+ channel activity been recognized, and some diversity of effects has been reported in different preparations. We report studies of protein kinase A-dependent phosphorylation effects on cardiac Na+ current using the macropatch o...
متن کاملElectrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block
BACKGROUND Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine and verapamil). Thus, identifying ECG signs of late sodium current block could aid in the determination of proarrhythmic risk for n...
متن کاملLeaching Kinetics of Stibnite in Sodium Hydroxide
Spherical pellets of antimony sulphide were dissolved in 1 molar sodium hydroxide solutions at different temperatures. It was found that the shrinking core with ash layer model could satisfactorily explain the dissolution process. Using this model it was found that initially the rate controlling step is a chemical reaction with activation energy of 10.2 kJ/mol. As the ash layer builds up, diffu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1984
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(84)84100-4